No mention of Super Milk Chan or Great Teacher Onizuka yet? wow. I don't watch nearly enough anime to form a "best of" list, but these two are right at the top anyway.
GTO? thats something I didn't expect to be mentioned here as a moves you kinda thing, but it is absolutely fantastic. Its a must watch at least once, though that does take time for its sheer length. (but not one episode is a pile of crap unlike a lot of long animes)
Reddyne pretty much mentioned the first things that came to my mind, Though promised place the plane annoys me with its twin propeller that makes no sense. Sure I know its not about the plane. It just annoys me :V
I'd recommend spice and wolf to anyone who hasn't seen it. Great change of pace to most stuff, and quite subtle, not in your face at all. Infact, I might think about watching that again soon now I've mentioned it.
Ghost in the shell is kinda meh to me now. I did love it and all of its spin offs when I first saw it, and its what got me into anime in the first place, but what bugs me about it is the words. SO. MANY. WORDS. It just piles on words to the point where it starts to feel very obvious that they are adding conversation in to make it feel clever because you haven't a fucking clue what they're talking about. :V (or maybe I just didn't get it? "D-4 LOADOUT!") But admittedly, I still enjoy it. the 2nd episode of stand alone complex with the tank is awesome, so are the tachikomas.
HOTD would have been good if it wasnt for all that damn fanservice. :ohdear: its more like HighschooloftheDAAAYYYM. ( I just mentioned it because I watched it recently and that bloody annoyed me as it would have been awesome without it. )
Oh how about last exile? It was quite the eyecandy to watch and loved the style. Dunno about plot and all that for moving. I don't remember really lol. Just know it was pretty :V