Don't forget Wriggle will probably chomp your head off in instinct after getting 'intimate'.
Letty - Frostbite, much? Kissing her would probably be like licking a frozen pole.
Suwako - Like real frogs, you'll need to sit on her back. FOR WEEKS.
Remilia & Flandre - I doubt there is much spare room in a coffin.
Medicine - Not only is she poisonous, she's also made OF WOOD. Hugging that doesn't feel pleasant. And watch out for splinters. Poisonous splinters.
Yuuka/Yuugi/Suika - Ever watched that Futurama episode where you saw the skeletons of the poor sods who got it on with giantesses? Yeah, that's how you're going to end up.
Eirin - Like Kaguya she's seen it all. And don't forget the multitude of organs-in-jars and questionable drugs laying around everywhere.
Tewi - Pedo, and have fun caring for a dozen trickster baby bunnies in five weeks.
Nazrin - Mouses need to eat their own body weight in food every day. You're going to run out of money sooner than you think.
Ichirin - Tell me, how is it like to have a colossus made out of clouds and testosterone breathing down your neck every day?
Byakuren - All your money is going to charity, whether you like it or not.
Aya/Hatate/Mystia/Utsuho - Don't be surprised when your feathered lover reveals that the eggs you are currently eating were laid by herself. (Bird menstruation involves laying unfertilized eggs)
Iku - Same as above, but with caviar instead.
Nitori - Not only do you have all those creepy tales about kappas, but Nitori probably smells like motor oil 24/7. Expect every room to be stacked with potentially lethal gadgets too.
Komachi - Her job and hardcore boss won't give her much free time to go out on a date with you.
Koakuma - Bye bye, soul.