I began typing this earlier and got interrupted but I'll post it anyway.
In other words, if you have lots of Two Prong Attacks (tpa), make lots of 4-matches of the primary color. If you have lots of rows, make lots of individual horizontal rows. The game of calculates them as distinct if you can actually see the combo number show up. A full board of light like that is only one combo. More combos = more damage, so for no awakenings at all, or unconditional leads, generally you would like to do as many combos as you can while also matching as many distinct sets of your primary attacking color as you can, light in your case. If using orb changing skills, you want to leave enough space to make those distinct combos instead of making one big blob of a single combo.
E: to elaborate, tpa or two prong attacks, refer to the awoken skill that looks like a U with arrows on both ends. Any monster with this skill will get an attack boost of x1.5 for each tpa awakening they have and additionally also attack two monsters (but not twice on a single enemy) when matching exactly a 4-orb combo.