So I watched a bunch of Awoken Isis vids
AndroReine is used in almost every single one of them. Pretty much the staple core of the team and somehow the REM blessed me with both of them. Obviously gungho finally decided to reward me for my years loyalty and devotion to the best girl :V
As for the other two subs it's a bit more of a toss up. One of them has to be Dark, so either Karin, Bodin, or Unevoed Amon. Although you can also tech in a non water for utility depending on the dungeon. Like one guy used Vegeto to nuke the fatty dragon and someone else used Bonia just so that they would have enough HP to tank DQ Hera's premptive :V.
Final sub is more up in the air, but the most common picks are Merlin, Hermes, or PadZ Sieg. Sieg in particular is an interesting choice since he has good awakenings, is a double orb changer, and also grants a 50% damage shield which can be useful for stopping DQ Hera's ridiculous preemptive. Hopefully we get him here...
I haven't seen anyone do Challenge 10 yet, but for everything else her burst is fine. AndroReine combo deals around 7-10+ million so it's enough to one hit any final boss, and you can pick your other two subs to best handle the other bosses.
The real main thing she needed to be in the best leader tier though is if only she got that 30% shield. Then her tankiness would be ridiculous which would allow her to stall vs any boss for the AndroReine combo to come up. In that respect Awoken Lakshi is better since she has around the same damage but also ridiculous tanking stats. Oh well tradeoff for being ez modo I guess.
So as for me, although I have Andro and Reine, I don't any any of the others.
The obvious pick would just to go with Wada and Sieg since they cover the right colors, and with Wada I have 100% skill lock resist.
However then I realized I have another really good sub that would let me hit 100%, D.Kali! :V
Although I lose out on damage by missing out on a row and not being water, I gain a shitton of utility with time+, skill boosts, and a fullboard active.
Final sub I should probably just use Nut cause she's hypermaxed anyways so :V. Hopefully gungho makes her ulti evo Water/Dark so then if I ever get a Karin I can go Awoken Karin.