The Binding of Isaac: Rebirth

[Bio]

Triple homing brimstone is amazing. I love it.
Gave a seed to my friend, and told him to skip the Brimstone and run with Monstro's Lung + Ipecac. Equally potent.

[Raikaria]

I just had a run where I got my 2nd Heart kill [As Issac this time].

Quad Shot + Cursed Eye + 20/20 = SHOTGUN. It got upgraded to a semi-automatic shotgun when I found a Tears Up item. Also had Guppy's Head and the Pentagram so my damage was alright.

I also unlocked Sampson.

[Yookie]

Challenge 13 is beans.

I'm going through the challenges and Nr.7 has to be the best thing ever. Barely didn't manage to complete it though.

Cursed Eye

I avoid picking this up most of the time because it has a chance to randomly warp you around when taking a hit. Messed me up a few times. :V
But if you can ensure heavy hits with it then I guess it's alright. Or with some sort of invincibility. (Book of Shadows comes to mind.)

[Raikaria]

Challenge 13 is beans.

I'm going through the challenges and Nr.7 has to be the best thing ever. Barely didn't manage to complete it though.
I avoid picking this up most of the time because it has a chance to randomly warp you around when taking a hit. Messed me up a few times. :V
But if you can ensure heavy hits with it then I guess it's alright. Or with some sort of invincibility. (Book of Shadows comes to mind.)

I keep forgetting what it is.

Still; Quad Shot + 20/20 + Cursed Eye. That shotgun is not something you pass up. Although it did screw me twice against The Gate.

[Serela]

Cursed Eye is like a horrible run ender to me, the chance feels like it's 75% to get warped on hit so if you aren't overwhelmingly strong then bosses can be nearly impossible. The charge effect isn't even all that great imo, I had really high Tears when I got it and I really think optimal charge shooting was LESS than I was shooting before, for a lot more input pain. (If you have quad shot+20/20 it might be ridiculously gigantic enough to be good, but even then not worth the warps)

The Solar System challenge is a nightmare if you don't get, like, mini brimstone. :C Some bosses are nearly run-enders if you get them just because getting close is ultra-doom (Don't even want to think about Mom/Mom's Heart; bible plzzzzzzz) I also regret ever unlocking Necropolis, dear mother of jesus it double-spawns on like all of my challenges and it's awful.

[Yookie]

I keep forgetting what it is.

13 is "Beans!" and starts you with 99 bombs, Butt bombs, Black Bean, 9 Volt, that Space-Bar Bean and the inability to shoot.
I got  Clubs card halfway through that put me back to 99 bombs, Brother Bobby + BFF and replaced the Bean with Guppy's Head. :V I ended the run with 8 bombs because hitting Red Mom with bombs is nearly impossible.

7 is "Suicide King where you have Mr. Mega, my reflection & Ipecac. You have to beat Satan.


On a side-note: It's possible to pause buffer the game. Frame perfect glitches incoming? :V

[Serela]

Beat Solar System because I got the bible for free mom/mom's heart kill, Holy Mantle for a negated hit every room, and a full health pill multiple times (including utero 2), I probably would have been doomed if all of that hadn't happened. XD

[Raikaria]

I beat

Spoiler:

boss Rush

as Issac.

Nothing special; just some damage ups; lil'Brim; Pyromaniac [The heal on explosions thing] and Thin Odd Mushroom+Toothpicks [Which seem to ber showing up every run]

Got the Peeper from it. Then beat Mom's Heart.

Also unlocked Eve. Just Judas, Blue Baby and ... something else that is a spoiler to unlock.

[CF7]

And i am still struggling to beat the Heart for the first time. Halfway through the fight it goes all bullet hell on me and i always die. Any tips?

[Raikaria]

And i am still struggling to beat the Heart for the first time. Halfway through the fight it goes all bullet hell on me and i always die. Any tips?

1: Pretend it is Touhou. Most of the bullet hell attacks are actually easily avoidable by tiny sidesteps. Think of it as streaming.
2: Kill summons ASAP, streaming while fighting adds is basically impossible. Heart and Adds both deal the same damage.
3: Try to go in with Spirit Hearts/Good HP. Every run where I have beaten the Heart I have not reached it having spent anything more than 2 Heart Containers on Devil Deals.

[Serela]

Some of the heart's bullet hell phases are a lot better to dodge from the sides instead of the bottom, too, because it gives you more room. And yes, kill summons quickly.

[Mew seeker]

If you have unlocked the

Spoiler:

Book of Secrets

, you can give it a try with this seed :
qyzm
g8bh
It should be on the first floor treasure room.
If you have not unlocked it, you'll get Brother Bobby instead.  :V

[Serela]

The

Spoiler:

Book of Secrets

isn't all that interesting anyway, it just

Spoiler:

reveals a random aspect of your map when you use it.

[FlamingRok]

Finally had my first death with Azazel. Turns out that

Spoiler:

Anti-Gravity Tears mixed with the Brimstone looks really cool, but isn't very practical.

Oh well, it was a nice six win streak anyways.

[Yookie]

The BASEMENT seed is way too amusing.
The game starts breaking after a while though. :V Very soon all pills were replaced with Tarot Cards, after a while my familiars were mostly gone and some things malfunctioned like Taurus being active 90% of the time and even through different rooms.

Also, every item was Rotten Milk at around Basement 50. Except for the Devil Deals, which I avoided to get Angel Rooms. :V

The best thing must have been the Remote Controlled Tooth-Tears with a ton of tear-effects. It was one big tooth that got bigger the closer it came to me, was flashing different colors and had three smaller teeth orbiting it that were flashing too.

[FlamingRok]

Also it appears when you have fifty or so spiders on screen and a fuck ton of other minions, you start to have trouble getting through doors, opening chests, or picking up other items.

Though I'm confused on how every item for you was Rotten Milk around that floor. For me, I was still getting varying items. I also took literally every devil deal. It was glorious. 

[MatsuriSakuragi]

Hoooooly shit that was a fun run. Did it with Eve and it was looking pretty horrid at first but I won.

I have never made it to or even seen

Spoiler:

The Cathedral

before and I beat it before ever beating Sheol, too.

Also: A fun combo is Pyro (99 bombs), Lucky Rock (rocks always drop coins), and Magic Fingers (uses a coin to damage every thing on screen). You'll pretty much be able to use it nonstop!

Seed is FM1R T92V. Screenshot showing everything I obtained in the run.

Spoiler:

You start out REALLY weak at first and then you get Daddy Longlegs and some items that basically make you a huge short range high speed splash bomb. Not strong by any means but fun as hell. Isaac is almost like a Touhou boss, holy shit.

[Yookie]

Though I'm confused on how every item for you was Rotten Milk around that floor. For me, I was still getting varying items. I also took literally every devil deal. It was glorious. 

I have no clue either, since there some items I definitely didn't pick up from the bosses. I had the "more options" thing so I had to not pick up some things but maybe those get taken out of the item-pool too.
Or it was just the game breaking from abuse. :V

[Shizumarashi Mayuzumi]

Also I learned (from reading, not from getting it yet myself sadly) how special seeds are getting found so quickly -

Spoiler:

one of the new card drops (Rules Card unlocked from challenge #11) apparently tells a special seed on use, among other fortune machine-y cryptic shit

.

[Smashy]

So I just tried Azazel for the first time, and get a Guppy transformation and some damage (mostly via Whore of Babylon).

Satan's third for stomps me once and instantly dies to about 20 attack flies  :justasplanned:

[Third Eye Lem]

Also I learned (from reading, not from getting it yet myself sadly) how special seeds are getting found so quickly -

Spoiler:

one of the new card drops (Rules Card unlocked from challenge #11) apparently tells a special seed on use, among other fortune machine-y cryptic shit

.

Huh, that's pretty neat. I'll have to give it a shot, then.

I just beat

Spoiler:

The Cathedral

with Blue Baby not too long ago. Was originally just gonna kill Mom's Heart but then the Angel Room opened up and I was all like "well, it's go for it!" I tore the place up, though I ended up stumbling around for a good while because of Curse of the Lost. >.< Proptosis is probably my new favorite damage upgrade, it's just so powerful without most of the drawbacks of stuff like Polythemus or Third Eye, even at long range. I really tried to go for a no-damage run on

Spoiler:

Isaac

but it was ruined by

Spoiler:

his wave of light pillars of death and doom.

I still won with plenty of health, though (and I even got Mama's Boy somehow). :V Maybe it is I that needs to be nerfed...! Or start playing Isaac on PC again. I love the Vita version too much for some reason.

Speaking of OP...

Spoiler:

Isaac now holds the D6!

Maybe I'll get started on Hard Mode now...After I do a couple more challenges first.

[MatsuriSakuragi]

I really tried to go for a no-damage run on

Spoiler:

Isaac

but it was ruined by

Spoiler:

his wave of light pillars of death and doom.

I noticed that in most cases, the corner opposite from when those start is generally a safe spot.

[Third Eye Lem]

I noticed that in most cases, the corner opposite from when those start is generally a safe spot.

Yeah, but it doesn't always work...But oh well, there's no

Spoiler:

"Church Boy"

achievement so it's not a big deal if I take a hit or two.

[LaserTurtle]

Here's a seed for all you people who want to have a fun, max damage by basement 2 run: XMN9 C7MS

Not joking. Floor 1 item is robo-baby and Experimental Treatment (if unlocked) after the boss, Basement 2 has Magic Mushroom in the item room and the Halo as prize for the boss room. If you get the devil room to show up, you'll find the Mark in there.

Later item rooms include

Spoiler:

triple shot and the wafer

. You'll also run into ridiculous amounts of luck up pills and cash.

Spoiler:

Played as Azazel, murdered the boss rush and Satan running on only 2 heart containers. Feels good to twoshot Satan's final form.

[CF7]

Sometimes i have bad runs, sometimes i have good runs, sometimes i beat Mom without taking damage and die on the next floor. And sometimes i get something very... special. ROLE 6EEX. Item pickups from item rooms and bosses are mandatory. Just try to clear it. I dare you.
P.S. Still haven't beaten the Heart.

[Mew seeker]

Seed is FM1R T92V. Screenshot showing everything I obtained in the run.

"What is this horrible creature?"  :V

[Bio]

Spoiler:

Well The Lost is fucking impossible to unlock.

Do Mullibooms even exist.

Spoiler:

In case anyone else wants to unlock this super secret character:
1. Die from a Mulliboom as Isaac on Basement/Cellar
2. Die from bombing yourself as Magdalene on Caves or equivalent.
3. Die from being stomped on by Mom's Foot as Judas.
4. Die to second stage Satan (lasers and bullets) as Azazel.
All in one sitting, no other deaths in between. Resetting runs is okay as long as you do it before the death screen. You can also die technically, but you must instantly pause and reset before the death screen  appears.

Spoiler:

As for The Lost itself, you have no HP, so any one hit is death. You cannot gain additional health in any way (not even evil/soul hearts). However deals with the devils are free and you start with flight

[CF7]

Sometimes i have bad runs, sometimes i have good runs, sometimes i beat Mom without taking damage and die on the next floor. And sometimes i get something very... special. ROLE 6EEX. Item pickups from item rooms and bosses are mandatory. Just try to clear it. I dare you.
P.S. Still haven't beaten the Heart.

Normally that run is a horrible mess of not being able to kill anything.
I tried it with Azazel. In short - total success.
A bit longer explanation:

Spoiler:

Starting short-range Brimstone + Gravity Bullets (first treasure room) = Circle Laser. Which is quite handy.
Starting short-range Brimstone + Gravity Bullets + Boomerang Bullets + Tammy's Head = A Sphere of Murderdeath that one-shots anything. Mom. The Gate. Mom's Heart. Anything. And it can be used once per room.

Whoa.

[Serela]

Spoiler:

Well The Lost is fucking impossible to unlock.

Do Mullibooms even exist.

More common in the Cellar, and I've heard they only do half a heart of damage, so if you see them you'll likely want to bomb the door out of the room (isaac starts with a bomb) and damage yourself before walking back in.

Thankfully the next two aren't very hard at all and Azazel is probably the best to have to get that far in the game with.

Also, as a warning; I hear you can't unlock that before you beat

Spoiler:

The Dark Room

, which for those who don't want to risk reading can rest assured if they didn't obtain a not-mom-heart-unlock ending that wasn't in the original game they haven't done so.

[Raikaria]

Am I the only person who can't play Azazel to save their life?

I'm awful at close range fighting in Issac, and unless you get one of a selection of items you stay CQC, which is practically a death sentence against Heart and bosses after that.

He's great early but he's kinda a disc one nuke because of his very limited range imo. I haven't even beaten Mom with him, while I'm pretty reliably beating her with Cain/Issac now, and Issac doesn't have the D6 yet.