Just cleared Hera-Is (certainly making myself late for work in the process). Nothing really went wrong except for one dropped combo on the fifth floor that didn't really matter that much (although if I had cleared Chaos Devil Dragon one turn faster I would've gotten one turn of I&I enhance on Hera, but it didn't turn out to matter either) and I forgot to turn on King Shynee on my huge burst AGAIN, but that worked out too. And for once I got a decent idea of how much damage my big finisher actually does. With one water row, one wood row, most but not quite all of the remainder of the screen being water (another row) and one water skyfall I did around 1.2-1.3 million with no other boosts after Hera's negligible defense. None of that was light or fire damage, so King Shynee and Echidna didn't get in on the attack, and nothing was resisted or super-effective. Yeah, working in Ruka (or Sun Quan...) here would make a big difference.
But of course she DIDN'T DROP (well, she dropped a chest like a goddamn troll), which makes me what, like 0/6 on descend bosses dropping on my first clear? Whatever, I can do this three more times today and I'll probably rank up as well, so I get more tries. I didn't notice anything that looks like it could go too horribly wrong aside from chain binds on the first floor, but I guess if I have to I can probably stall out 6-9 turns of bind.