I do actually like games where you're not the strongest thing in the world ever and you rise above your enemies merely through skill and intelligence alone. Especially things where your enemy is faster and stronger than you in every way.
Things like Chris and Sheva vs Wesker, Leon vs Krauser, and probably my favorite example is Snake vs Liquid.
Especially since you learn that all along, Liquid had all the "superior" genes while Snake had all the recessive ones.