Entering day 4 in Fallout 4.
It's more about ironing out a number of loose ends as opposed to anything else. I've run the course with Piper, Nick, and soon Curie with only Danse to go. Things are settling in and I may soon be done until the DLC comes around. After a while, certain pieces of gear that are a cut above everything else become the only things you use and certain missions begin to repeat in familiar locations. Still, exploring is always rewarding and if you play around with the settlements, you'll always have something to build up and scavenge for. The downside is that once you hit this stride, you're effectively invincible unless you boost the difficulty or charge headlong into dangerous situations. Mind you, it took 50-60 hours to do so.
The game does have its weaknesses around certain other things. It's true about the game being glitchy. Some quests are quite forgettable and will even repeat ad nauseam with your faction of choice. Characterization isn't all that strong or memorable most of the time. Melee combat sounds fun until one stray raider blocks 5 of your attacks in a row and counters with their own, making melee not only a cumbersome reliability, but really just not satisfying. On the other hand, you can pop them in the face once and they'll explode.
In the end, your enjoyment of the game still really does boil down to enjoying what it gives you. Exploration, settlement building, and weapon customization are all great places to invest your time and naturally lead into one another, creating a comfortable cycle of going out to a location, gutting it of enemies and supplies, building up your homestead(s) of choice, then prepping yourself for the next trek into the wastes. If that's your schtick, you'll get more than your share.
Also, after some 80 hours of playtime I am finally entering the Glowing Sea for the first time. It's deliciously haunting and atmospheric to the point that it rivals The Glow in the original. Even though I'm kitted to the gills I still went through some truly special prep to ready myself for it.