Well if it's just interesting comics you're interested in, here are my favorites:
Touhou 4koma by Setz is very unique both in art style and content because the artist is from Finland. It's not very narrative, but many of the jokes are great and the art is very interesting. Setz doesn't draw Touhou as much any more, but he still posts stuff from time to time. He also wrote a narrative doujin with a similarly unusual European twist that I like a lot.
Touhou Party Barrel by Karaagetarou is fantastic. Karaage is the absolute best thing that's ever happened to the Touhou fandom in my opinion. His stories and art are excellent and absolutely unique. His 4komas are funny and adorable, and if you like those definitely check out his narrative doujins because they're stupendous. Karaage's books are the only doujin comics I regularly import.
I just finished reading
SexuAlice by Sei earlier today and liked it quite a lot. It's sort of NSFW (I don't think there's actually anything explicit in it, but basically all of the humor is sex-based) and it tends to lean too hard on the same few jokes, but I like the artist's style a lot and it remains mostly funny throughout despite a lot of repetition. There's a running gag involving
that has Sideshow Bob syndrome, where it repeats so many times that it stops being funny after a while, but then becomes hilarious when it just keeps on going after that. As an added bonus it looks like it recently started updating again after a hiatus.
Edit:
For more contemporary and at least semi-regularly updating fare,
Hakurei-San's Leisurely Walk by Chamaji is a very good recent comic. It's a dialogue-free comic about a mellow Reimu who entertains a revolving door of youkai guests at her shrine and the art style is interesting. The artist draws each character with a different style of eyes, and some of them look pretty wild.