Deus Ex
Funny enough, I picked up an interest in this one recently and even watched the old runs. Great stuff, let's see how it goes this time.
Shadow Warrior (finally!)
SECONDED
What else...
BTDD co-op - This is gonna be good
Castlevania: CotM - About damn time for a different Igavania to be shown off!
Cuphead - TMR is god
Dark Souls - All Bosses run should be curious
PoP: WW - Still looking forward to it
Redneck Rampage - Another Build engine game? Oh well, I'll take it
Jedi Knight - This one's awesome. Never seen the expansion, will be curious
Super Smash TV - I'm a fan of Total Carnage, the "sequel" of this one, so it'll be fun to see a co-op run here
Super Metroid is back but appears to not be a race this year! Interesting.
By the looks of it, there'll be a Zero Mission race.