Well, I think the English version isn't compatible with any unofficial patch, so you'd need to play in japanese.
Also, which patches do you want? There are many of them. Emerald is obviously not compatible with anything. For the others, look at the wiki first for some pointers.
The Lunatic one has most of what the others have (Dark/Last Word/Final Touhoumons, Johto region, SA dungeon, etc.), but the difficulty is really high. It's not too bad if you know what you're doing, but if you give your Touhoumons crappy movesets you'll be grinding constantly.
Get the TouhouDex 1.53. It'll tell you what moves you can get, bases stats and all that, and is pretty much necessary to play in japanese.